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MOAN-CB

MOAN-CB: Modelling and Analysis of Cell Behaviour

23 september 2009

Warwick (UK)

Room MS.01

This workshop will be devoted to computational support for Systems Biology. Our aim is to bring together people from bioinformatics, computer science and biology.

In particular, we focus on modeling and analysis techniques for various regulatory networks. Examples are genetic regulation, metabolic processes, and signalling pathways within a cell. The interaction between such networks is of special interest.

We welcome presentations on integrated modeling techniques, e.g. using differential equations, or using (probabilistic) discrete models. Furthermore, contributions on scalable analysis methods are welcome, such as system reduction, and model checking techniques, in order to identify crucial properties of (emerging) cell behaviour.

The workshop is organised by the EC-MOAN project, and consists of presentations from people both within and outside the project. There will be plenty of time to discuss in which direction the research field should move.

09:00-10:00 EC-MOAN session 1: Modelling
09:00-09:20 Goals and Results of the EC-MOAN project
Jaco van de Pol (U Twente, NL)
09:20-09:40 Omnipresent two-component signaling governs swift and robust responses even at low molecule numbers
Frank J. Bruggeman (VU Amsterdam, NL)
09:40-10:00 Modelling ammonium assimilation regulation in Escherichia coli
Hongwu Ma (Edinburgh University, UK)
10:00-10:30 Coffee break
10:30-11:30 Session: Methodology
10:30-11:00 Modelling biochemical pathways with Bio-PEPA and CTMCs
Jane Hillston (Edinburgh University, UK)
11:00-11:30 Sound identification and model merging when studying type 2 diabetes
Gunnar Cedersund (Linköping University, SE)
11:30-12:30 Session: Stochastic Process Algebra
11:30-11:50 Stochastic automata for replication, translation and translesion synthesis
Erik de Vink (TU Eindhoven, NL)
11:50-12:10 Process algebraic modelling and analysis of signalling pathway crosstalk
Robin Donaldson (Glasgow University, UK)
12:10-12:30 Modelling scaffold-mediated crosstalk between the cAMP and the Raf-1/MEK/ERK pathways
Oana Andrei (Glasgow University, UK)
12:30-14:00 Lunch break
14:00-15:00 EC-MOAN session 2: Analysis
14:00-14:20 Qualitative analysis of carbon starvation response in E. coli
Valentina Baldazzi (INRIA Grenoble, FR)
14:20-14:40 On Computational Analysis of Large ODE Models
David Safranek (Masaryk University, Brno, CZ)
14:40-15:00 Modeling kinase signalling pathways in cells using UPPAAL
Rom Langerak (U Twente, NL)
15:00-16:30 Session: Quantitative Analysis
15:00-15:30 A general computational method for robustness analysis with applications to synthetic gene networks
Gregory Batt (INRIA Rocquencourt, Fr)
15:30-16:00 Executing Multicellular Development: Quantitative Predictive Modelling of C. elegans Vulva
K. Anton Feenstra (VU Amsterdam, NL)
16:00-16:30 BioModel Engineering and its role in Systems Biology
David Gilbert (Brunel University, UK)
16:30-17:00 Tea break
17:00-18:00 Panel Discussion

Organizers

Frank Bruggeman (VU Amsterdam) and Jaco van de Pol (U Twente)

Co-located with

European Conference on Complex Systems, ECCS 2009

Linked with

EC-MOAN (FP6 NEST)