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Alzheimer’s disease; Chiral complexes target amyloid β

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Stereochemistry is a very important issue for pharmaceutical industry and can determine drug efficacy. Scott group metallohelices have been shown, in collaboration with Xiaogang Chu and co-workers at Changchun Institute of Applied Chemistry, China, to enantioselectively target and inhibit amyloid (Aβ) aggregation. This provides new insights into chiral inhibition of Aβ aggregation and opens a new avenue for design and screening of chiral agents as Aβ inhibitors against Alzheimer's disease. The work is published in J. Am. Chem. Soc.

Thu 31 July 2014, 21:56 | Tags: publications AnalSci&Inst Synth&Cat ChemBio