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Dr. Claudia Blindauer

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Dr. Claudia A. Blindauer

Associate Professor (Reader) of Chemistry

Dipl.-Chem., PhD University of Basel, Switzerland; FRSC

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Research Summary
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We are working in the field of inorganic biochemistry, focusing on metal-binding proteins from a variety of organisms including mammals, invertebrates, plants, and bacteria, with the aim to contribute to the understanding of mechanisms of metal ion homeostasis. Protein structure, dynamics of metal uptake and release, and biomolecular interactions are studied using recombinant protein expression and purification, multinuclear NMR, mass spectrometry, optical spectroscopies and multi-elemental analysis.

Selected Publications (a more comprehensive list is here or at ResearcherID)
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Circulatory Zinc Transport is Controlled by Distinct Interdomain Sites on Mammalian Albumins.
K. B. Handing, I. G. Shabalin, O. Kassaar, S. Khazaipoul, C. A Blindauer, A. J. Stewart, M. Chruszch and W. Minor, Chem. Sci., 2016, DOI: 10.1039/C6SC02267G.

Unexpected Interactions of the Cyanobacterial Metallothionein SmtA with Uranium.
C. Acharya and C.A. Blindauer, Inorg. Chem., 2016, 55, 1505–1515. DOI: 10.1021/acs.inorgchem.5b02327.

Advances in the Molecular Understanding of Biological Zinc Transport.
C. A. Blindauer, Chem. Commun., 2015, 51, 4544-4563. DOI: 10.1039/C4CC10174J.

Identification of major zinc-binding proteins from a marine cyanobacterium: insight into metal uptake in oligotrophic environments.
J. P. Barnett,D. J. Scanlan and C. A. Blindauer, Metallomics, 2014, 6, 1254-1268.DOI: 10.1039/C4MT00048J.

Lessons on the critical interplay between zinc binding and protein structure and dynamics.
C. A. Blindauer, J. Inorg. Biochem. 2013, 121, 145-155. DOI:10.1016/j.jinorgbio.2013.01.005.

Allosteric Inhibition of Cobalt Binding to Albumin by Fatty Acids: Implications for the Detection of Myocardial Ischemia.
J. Lu, A. J. Stewart, P. J. Sadler, T. J. T. Pinheiro and C. A. Blindauer, J. Med. Chem., 2012, 55, 4425-4430.
DOI: 10.1021/jm3003137.

A molecular mechanism for modulating plasma Zn speciation by fatty acids.
J. Lu, A. J. Stewart, D. Sleep, P. J. Sadler, T. J. T. Pinheiro, and C. A. Blindauer. J. Am. Chem.Soc. 2012, 134, 1454–1457. DOI: 10.1021/ja210496n.

Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms.
O. I. Leszczyszyn, S. Zeitoun-Ghandour, S. R. Stürzenbaum and C. A. Blindauer. Chem. Commun., 2011, 47, 448-450. DOI: 10.1039/C0CC02188A.

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more.
C. A. Blindauer, O. I. Leszczyszyn, Nat. Prod. Rep. 2010, 27, 720-741.