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Publications

Patents

11) D. J. Grainger and D. J. Fox, ‘Anti-inflammatory agents’ WO 2011154696 2011. http://www.google.com/patents/WO2011154696A1?cl=en

10) D. J. Grainger and D. J. Fox, ‘Anti-inflammatory agents’ WO 2011154695 2011. http://www.google.com/patents/WO2011154695A1?cl=en

9) D. J. Grainger and D. J. Fox, ‘3-(2',2'-Dimethylpropanoylamino)tetrahydropyridin-2-one for treatment of inflammatory disorders’ US 20090036486 2009. http://www.google.com/patents/US20090036486 see also D. J. Grainger and D. J. Fox, ‘ Anti-inflammatory composition comprising 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one’ WO 2009016390 2009. http://www.google.com/patents/WO2009016390A1?cl=en

8) D. J. Grainger and D. J. Fox, ‘Apoe mimetic agents for preparing a medicament intended to prevent or treat inflammatory or neurodegenerative disorders’ WO 2007020386 2007. http://www.google.com/patents/WO2007020386A3?cl=en

7) D. J. Grainger and D. J. Fox, 'Preparation of acylaminocaprolactams as antiinflammatory agents' WO 2006016152 2006 http://www.google.com/patents/WO2006016152A1

6) D. J. Grainger and D. J. Fox, 'Ligands for G-protein coupled receptors' Wo 2006024815 2006.

5) D. J. Grainger and D. J. Fox, 'Anti-inflammatory agents' Wo 2006018609 2006.

4) D. J. Grainger and D. J. Fox, 'Thiofoxins, dimethylthiofoxins, azafoxins and amidofoxins which may be useful as ligands for G-protein coupled receptors' GB 2423085 2006.

3) D. J. Grainger and D. J. Fox, '3-Acylaminocaprolactams containing a mono- or poly-cyclic cyclo-alkane or -alkene group in the acyl moiety for treatment of inflammatory disorders' GB 2418425 2006.

2) D. J. Grainger and D. J. Fox, 'Alpha-(acylamino)-bicyclolactam derivatives for treatment of inflammatory disorders' GB 2418426 2006

1) D. J. Grainger and D. J. Fox, 'Preparation of 3-aminocaprolactam derivatives as anti-inflammatory agents' Wo 2005053702 2005.

Journal Papers

67) Mitchell, Daniel E., Clarkson, Guy J., Fox, David J., Vipond, Rebecca A., Scott, Peter and Gibson, Matthew I.. "Antifreeze protein mimetic metallohelices with potent ice recrystallization inhibition activity." J. Am. Chem. Soc., 2017, 139, 9835-9838. http://doi.org/10.1021/jacs.7b05822

66) Niko Pavliček, Anish Mistry, Zsolt Majzik, Nikolaj Moll, Gerhard Meyer, David J. Fox and Leo Gross "Synthesis and characterization of triangulene" Nature Nanotechnology 2017, doi:10.1038/nnano.2016.305 

65) Zoe J. Anderson, David J. Fox "Total synthesis of the azolemycins" Org. Biomol. Chem., 2016, DOI: 10.1039/C5OB02520f

64) Ning Liu, Lijiang Song, Minghao Liu, Fei Shang, Zoe Anderson, David J. Fox, Gregory L. Challis and Ying Huang, "Unique post-translational oxime formation in the biosynthesis of the azolemycin complex of novel ribosomal Peptides from Streptomyces sp.FXJ1.264" Chem. Sci., 2016, DOI: 10.1039/c5sc03021h

63) Clark, Andrew J., Curran, Dennis P., Fox, David J. (David John), Ghelfi, Franco, Guy, Collette S., Hay, Benjamin, James, Natalie, Phillips, Jessica M., Roncaglia, Fabrizio, Sellars, Philip B., Wilson, Paul and Zhang, Hanmo. (2016) Axially chiral enamides : substituent effects, rotation barriers, and implications for their cyclization reactions. J. Org. Chem., 2016, 81, 5547-5565. http://dx.doi.org/10.1021/acs.joc.6b00889

62) Coe, S.; Pereira, N.; Geden, J. V.; Clarkson, G. J.; Fox, D.; Napier, R. M.; Neve, P.; Shipman, M. "Ring Closing Metathesis Reactions of alpha-Methylene-beta-Lactams: Application to the Synthesis of a Simplified Phyllostictine Analogue with Herbicidal Activity", Org. Biomol. Chem. 2015, 13, 7655-7663. DOI: 10.1039/C5OB00890E

61) J. J. Douglas, G. Churchill, A. M. Z. Slawin, D. J. Fox and A. D. Smith “Stereo- and Chemodivergent NHC-Promoted Functionalisation of Arylalkylketenes with Chloral” Chem. Eur. J., 2015, 21, 16354-16358 DOI: 10.1002/chem.201503308.

60) V. Nikolaou, A. Anastasaki, F. Alsubaie, A. Simula, D.J. Fox, D.M. Haddleton “Copper(II) gluconate (a non-toxic food supplement dietary aid) as a precursor catalyst for effective photo-induced living radical polymerization of acrylates” Polym. Chem., 2015, 6, 3581-3585.

59) A. Anastasaki, V. Nikolaou, F. Brandford-Adams, G. Nurumbetov, Q. Zhang, G.J. Clarkson, D. Fox, P. Wilson, K. Kempe and D.M. Haddleton, "Photo-induced living radical polymerization of acrylates utilizing a discrete copper(II)/formate complex” Chem. Commun., 2015, 51, 5626-5629

58) Michael S. Perryman, Matthew W. M. Earl, Sam Greatorex, Guy J. Clarkson and David J. Fox "Synthesis of 1- and 4-substituted piperazin-2-ones via Jocic-type reactions with N-substituted diamines" Org. Biomol. Chem., 2015, DOI: 10.1039/C4OB02311K

57) Anish Mistry, Ben Moreton, Bruno Schuler, Fabian Mohn, Gerhard Meyer, Leo Gross, Antony Williams, Peter Scott, Giovanni Costantini and David J. Fox "The Synthesis and STM/AFM Imaging of ‘Olympicene’ Benzo[cd]pyrenes" Chem. Eur. J. 2015, 21, 2011-2018. doi: 10.1002/chem.201404877

56) Alan D. Faulkner, Rebecca A. Kaner, Qasem M. A. Abdallah, Guy Clarkson, David J. Fox, Pratik Gurnani, Suzanne E. Howson, Roger M. Phillips, David I. Roper, Daniel H. Simpson, Peter Scott, Nature Chem. 2014, 6, 797–803. doi:10.1038/nchem.2024

55) Anastasaki, Athina; Nikolaou, Vasiliki; Zhang, Qiang; Burns, James; Samanta, Shampa R.; Waldron, Christopher; Haddleton, Alice J.; McHale, Ronan; Fox, David; Percec, Virgil; Wilson, Paul; Haddleton, David M. "Copper(II)/Tertiary Amine Synergy in Photoinduced Living Radical Polymerization: Accelerated Synthesis of ω-Functional and α,ω-Heterofunctional Poly(acrylates)" J. Am. Chem. Soc., 2014, 136, 1141–1149.

54) Perryman, Michael S.; Harris, Matthew E.; Foster, Jade L.; Joshi, Anushka; Clarkson, Guy J.; Fox, David J. "Trichloromethyl ketones: asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines" Chem Commun., 2013, 49, 10022-10024. DOI:10.1039/c3cc46070c This paper was highlighted in Synfacts 2014, 10, 175. DOI:10.1055/s-0033-1340532

53) Schuler, Bruno; Liu, Wei; Tkatchenko, Alexandre; Moll, Nikolaj; Meyer, Gerhard; Mistry, Anish; Fox, David; Gross, Leo, "Adsorption geometry determination of single molecules by atomic force microscopy" Physical Review Letters 2013, 111, 106103/1-106103/5 DOI:10.1103/PhysRevLett.111.106103

52) Morrill, Louis C.; Douglas, James; Lebl, Tomas; Slawin, Alexandra M. Z.; Fox, David J.; Smith, Andrew D. "Isothiourea-mediated asymmetric Michael-lactonisation of trifluoromethylenones: a synthetic and mechanistic study" Chemical Science, 2013, 4, 4146-4155. DOI:10.1039/c3sc51791h

51) Rushworth, Philip J.; Hulcoop, David G.; Fox, David J. "Iron/Tetramethylethylenediamine-Catalyzed Ambient-Temperature Coupling of Alkyl Grignard Reagents and Aryl Chlorides" J. Org. Chem., 2013, 78, 9517-9521. DOI: 10.1021/jo4016612

50) Dobrzanska, Dorota A.; Cooper, Amy L.; Dowson, Christopher G.; Evans, Stephen D.; Fox, David J.; Johnson, Benjamin R.; Biggs, Caroline I.; Randev, Rajan K.; Stec, Helena M.; Taylor, Paul C.; Marsh, Andrew, "Oxidation of Tertiary Amine-Derivatized Surfaces To Control Protein Adhesion" Langmuir 2013, 29, 2961-2970. DOI:10.1021/la4003719

49) Clark, Andrew J.; Collis, Alana E. C.; Fox, David J.; Halliwell, Lauren L.; James, Natalie; O'Reilly, Rachel K.; Parekh, Hemal; Ross, Andrew; Sellars, Andrew B.; Willcock, Helen; Wilson, Paul, "Atom-Transfer Cyclization with CuSO4/KBH4: A Formal "Activators Generated by Electron Transfer" Process Also Applicable to Atom-Transfer Polymerization" J. Org. Chem., 2012, 77, 6778-6788. DOI:10.1021/jo301429a

48) Gomez-Escribano, Juan Pablo; Song, Lijiang; Fox, David J.; Yeo, Valerie; Bibb, Mervyn J.; Challis, Gregory L. 'Structure and biosynthesis of the unusual polyketide alkaloid coelimycin P1, a metabolic product of the cpk gene cluster of Streptomyces coelicolor M145' Chemical Science, 2012, 3, 2716-2720. DOI:10.1039/c2sc20410j

47) Pounder, Ryan J.; Fox, David J.; Barker, Ian A.; Bennison, Michael J.; Dove, Andrew P. 'Ring-opening polymerization of an O-carboxyanhydride monomer derived from L-malic acid' Polymer Chemistry, 2011, 2, 2204-2212. DOI: 10.1039/C1PY00254F

46) Laura E. N. Allan, Guy J. Clarkson, David J. Fox, Andrew L. Gott, and Peter Scott, 'Mechanism of Catalytic Cyclohydroamination by Zirconium Salicyloxazoline Complexes' J. Am. Chem. Soc., 2010, 132, 15308–15320. DOI: 10.1021/ja106588m

45) Anthony J. Kirby, John E. Davies, David J. Fox, David R. W. Hodgson, Andr�s E. Goeta, Marcelo F. Lima, Jacks P. Priebe, J. Arturo Santaballa and Faruk Nome, 'Ammonia oxide makes up some 20% of an aqueous solution of hydroxylamine' Chem. Commun., 2010, 46, 1302–1304. DOI: 10.1039/b923742a

44) David M. Hodgson, Saifullah Salik and David J. Fox, 'Stereocontrolled Syntheses of (−)-Cubebol and (−)-10-Epicubebol Involving Intramolecular Cyclopropanation of α-Lithiated Epoxides' J. Org. Chem., 2010, 75, 2157–2168 DOI: 10.1021/jo9022974

43) Fung Kei (Kathy) Cheung, Adam J. Clarke, Guy J. Clarkson, David J. Fox, Mark A. Graham, Changxue Lin, Adriana Lorente Crivill�, Martin Wills, Dalton Trans., 2010, 39, 1395 - 1402 DOI 10.1039/b915932

42) Michael J. Brown, Guy J. Clarkson, David J. Fox Graham G. Inglis, Michael Shipman, 'Critical importance of leaving group ‘softness’ in nucleophilic ring closure reactions of ambident anions to 1,2-diazetidines' Tetrahedron Lett., 2010, 51, 382-384. doi:10.1016/j.tetlet.2009.11.024

41) David J. Fox, Jill Reckless, Hannah Lingard, Stuart Warren and David J. Grainger, ‘Highly potent, orally-available anti-inflammatory broad-spectrum chemokine inhibitors’ J. Med. Chem., 2009, 52, 3591–3595. DOI: 10.1021/jm900133w

40) Celia Clarke, David J. Fox, Daniel Sejer Pedersen and Stuart Warren ‘The lithiation and acyl transfer reactions of phosphine oxides, sulfides and boranes in the synthesis of cyclopropanes’ Org. Biomol. Chem., 2009, 7, 1329 - 1336. DOI: 10.1039/ b817436a

39) Celia Clarke, St�phanie Foussat, David J. Fox, Daniel Sejer Pedersen, Stuart Warren, ‘Asymmetric synthesis of trans-disubstituted cyclopropanes using phosphine oxides and phosphine boranes’ Org. Biomol. Chem., 2009, 7, 1323 - 1328. DOI: 10.1039/b817433d 

38) Hannah F. Sore, Christine M. Boehner, Simon J. F. MacDonald, David Norton, David J. Fox and David R. Spring, ‘Fluoride-free cross coupling using vinyldisiloxanes’, Org. Biomol. Chem., 2009, 7, 1068–1071. DOI: 10.1039/b900852g

37) D. J. Fox, S. Parris, Daniel Sejer Pedersen and Stuart Warren, '(1R,2R)-4-Benzoyl-2-benzoyloxy-1-phenylbutylimidazole-1-carboxylate' Acta Cryst., Section E: Structure Reports Online, 2008, E64, o619.

36) D. J. Fox, D. Sejer Pedersen and S. Warren, ‘(2S,4'R,5'R)-(E)-tert-Butyl 2-acetyl-2-(2-oxo-5-phenyl-1,3-dioxolan-4-ylmethyl)-5-phenylpent-4-enoate Acta Cryst., Section E: Structure Reports Online, 2008, E64, o530.

35) F.K. Cheung, C. Lin, F. Minissi, A. Lorente, M. A.Graham, D.J. Fox and M. Wills, ‘An Investigation into the Tether Length and Substitution Pattern of Arene-Substituted Complexes for Asymmetric Transfer Hydrogenation of Ketones’, Org. Lett., 2007, 9, 4659-4662.

34) P. Cassanelli, D. J. Fox and R. A. Cox, ' Temperature dependence of pentyl nitrate formation from the reaction of pentyl peroxy radicals with NO' Phys. Chem. Chem. Phys., 2007, 9, 4332–4337.

33) X. Su, D. J. Fox, D. T. Blackwell, K. Tanaka and D. R. Spring, 'Copper catalyzed oxidation of organozinc halides' Chem. Commun., 2006, 3883.

32) E. E. Wyatt, S. Fergus, W. R. J. D. Galloway, A. Bender, D. J. Fox, A. T. Plowright, A. S. Jessiman, M. Welch, and D. R. Spring, 'Skeletal diversity construction via a branching synthetic strategy' Chem. Commun., 2006, 3296.

31) D. J. Fox, T. J. Morley, and S. Warren, 'Episulfonium ion-mediated cyclic peptide and triazine synthesis' Org. Biomol. Chem., 2006, 4, 3120.

30) D. J. Fox, D. S. Pedersen, A. B. Petersen, and S. Warren, 'Diphenylphosphinoyl chloride as a chlorinating agent – the selective double activation of 1,2-diols' Org. Biomol. Chem., 2006, 4, 3117.

29) D. J. Fox, D. S. Pedersen, and S. Warren, 'Asymmetric synthesis of orthogonally protected trans-cyclopropane -amino acids via intramolecular ring closure' Org. Biomol. Chem., 2006, 4, 3113.

28) D. J. Fox, S. Parris, D. S. Pedersen, C. R. Tyzack, and S. Warren, 'Asymmetric synthesis of cyclopropanes and dihydrofurans based on phosphine oxide chemistry' Org. Biomol. Chem., 2006, 4, 3108.

27) D. J. Fox, D. S. Pedersen, and S. Warren, 'Diphenylphosphinoyl-mediated synthesis of ketones' Org. Biomol. Chem., 2006, 4, 3102.

26) D. S. Surry, X. Su, D. J. Fox, V. Franckevicius, S. J. F. Macdonald, and D. R. Spring, 'Synthesis of medium-ring and iodinated biaryl compounds by organocuprate oxidation' Angew. Chem. Int. Ed., 2005, 44, 1870.

25) D. S. Surry, D. J. Fox, S. J. F. MacDonald, and D. R. Spring, 'Aryl-aryl coupling via directed lithiation and oxidation' Chem. Commun., 2005, 2589.

24) D. J. Grainger, J. Reckless, and D. J. Fox, 'Broad spectrum chemokine inhibitors related to NR58-3.14.3' Mini-Rev. Med. Chem., 2005, 5, 825.

23) D. J. Fox, J. Reckless, S. M. Wilbert, I. Greig, S. Warren, and D. J. Grainger, 'Identification of 3-(Acylamino)azepan-2-ones as Stable Broad-Spectrum Chemokine Inhibitors Resistant to Metabolism in Vivo' J. Med. Chem., 2005, 48, 867.

22) D. J. Fox, T. J. Morley, S. Taylor, and S. Warren, 'Selective five- and six-membered cyclic amine syntheses via capture of episulfonium ions' Org. Biomol. Chem., 2005, 3, 1369.

21) T. Boesen, D. J. Fox, W. Galloway, D. S. Pedersen, C. R. Tyzack, and S. Warren, 'Asymmetric cyclopropane synthesis via phosphine oxide mediated cascade reactions' Org. Biomol. Chem., 2005, 3, 630.

20) D. J. Fox, D. S. Pedersen, and S. Warren, 'A simple, general and efficient ketone synthesis via alkylation and dephosphinoylation of b-keto-diphenylphosphine oxides' Chem. Commun., 2004, 2598.

19) J. Carlisle, D. J. Fox, and S. Warren, 'Thermodynamically controlled cyclization reactions with double phenylsulfanyl migration' Chem. Commun., 2003, 2696.

18) L. Caggiano, J. Davies, D. J. Fox, D. C. Moody, and S. Warren, 'Stereoselective substituted pyrrolidine and cyclic ether synthesis by PhS migration' Chem. Commun., 2003, 1648.

17) L. Caggiano, J. Davies, D. J. Fox, D. C. Moody, and S. Warren, 'Novel silica catalyzed stereoselective cyclic carbamate and carbonate rearrangements' Chem. Commun., 2003, 1650.

16) D. J. Fox, J. Reckless, S. G. Warren, and D. J. Grainger, 'Design, Synthesis, and Preliminary Pharmacological Evaluation of N-Acyl-3-aminoglutarimides as Broad-Spectrum Chemokine Inhibitors in Vitro and Anti-inflammatory Agents in Vivo' J. Med. Chem., 2002, 45, 360.

15) D. J. Fox, D. House, and S. Warren, 'Mechanisms of sulfanyl (RS) migrations: synthesis of heterocycles' Angew. Chem. Int. Ed., 2002, 41, 2462.

14) N. Feeder, D. J. Fox, J. A. Medlock, and S. Warren, 'Synthesis, X-ray crystal structures and Horner-Wittig addition reactions of some protected β-aminophosphine oxides' J. Chem. Soc., Perkin Trans. 1, 2002, 1175.

13) M. D. Eastgate, D. J. Fox, T. J. Morley, and S. Warren, 'Sulfur mediated Ritter reactions: the synthesis of cyclic amides' Synthesis, 2002, 2124.

12) L. Caggiano, D. J. Fox, and S. Warren, 'Silica gel catalyzed generation of episulfonium ions: a mild method for the synthesis of heterocycles' Chem. Commun., 2002, 2528.

11) L. Caggiano, D. J. Fox, D. House, Z. A. Jones, F. Kerr, and S. Warren, 'Asymmetric synthesis of tetrahydrofurans by competitive [1,2]-phenylsulfanyl (PhS) migrations under thermodynamic control' J. Chem. Soc., Perkin Trans. 1, 2002, 2634.

10) L. Caggiano, D. J. Fox, D. House, Z. A. Jones, F. Kerr, and S. Warren, 'Asymmetric synthesis of tetrahydropyrans with competitive [1,2]-phenylsulfanyl (PhS) migrations' J. Chem. Soc., Perkin Trans. 1, 2002, 2646.

9) S. D. Bull, S. G. Davies, D. J. Fox, M. Gianotti, P. M. Kelly, C. Pierres, E. D. Savory, and A. D. Smith, 'Asymmetric synthesis of β-pyridyl-β-amino acid derivatives' J. Chem. Soc., Perkin Trans. 1, 2002, 1858.

8) I. C. Baldwin, P. Briner, M. D. Eastgate, D. J. Fox, and S. Warren, 'Synthesis of Enantiomerically Pure 2,2,3,4,5-Pentasubstituted Pyrrolidines by Phenylsulfanyl Migration' Org. Lett., 2002, 4, 4381.

7) D. J. Fox, J. A. Medlock, R. Vosser, and S. Warren, 'Allene synthesis by an asymmetric Baylis-Hillman style reaction on vinylphosphine oxides' J. Chem. Soc., Perkin Trans. 1, 2001, 2240.

6) T. Boesen, N. Feeder, M. D. Eastgate, D. J. Fox, J. A. Medlock, C. R. Tyzack, and S. Warren, 'The chemistry of lithiated phosphine oxides: the stereoselective synthesis of alkene-4,5-diols' J. Chem. Soc., Perkin Trans. 1, 2001, 118.

5) D. J. Fox, D. House, S. Warren, and F. Kerr, 'Asymmetric synthesis of tetrahydrofurans and tetrahydropyrans with competitive [1,2]-phenylsulfanyl (PhS) migration. II. Synthesis of protected tetrahydropyrans' Chem. Commun., 2000, 1781.

4) J. Eames, D. J. Fox, M. A. de las Heras, and S. Warren, 'Stereochemically controlled synthesis of 1,8-dioxaspiro[4.5]decanes and 1-oxa-8-thiaspiro[4.5]decanes by phenylsulfanyl migration' J. Chem. Soc., Perkin Trans. 1, 2000, 1903.

3) L. Djakovitch, J. Eames, D. J. Fox, F. H. Sansbury, and S. Warren, 'Synthesis of cyclic ethers and allylic sulfides by rearrangement of phenylsulfanyl substituted 1,n-diols with toluene-p-sulfonic acid and with toluene-p-sulfonyl chloride' J. Chem. Soc., Perkin Trans. 1, 1999, 2771.

2) S. D. Bull, S. G. Davies, D. J. Fox, and T. G. R. Sellers, 'Chiral relay effects influence the facial selectivity of N-alkylated 5-phenylmorpholin-2-one enolates' Tetrahedron: Asymmetry, 1998, 9, 1483.

1) S. D. Bull, S. G. Davies, D. J. Fox, A. C. Garner, and T. G. R. Sellers, 'Chiral relay auxiliaries' Pure Appl. Chem., 1998, 70, 1501 (also as S. D. Bull, S. G. Davies, D. J. Fox, A. C. Garner, and T. G. R. Sellers, 'Chiral relay auxiliaries' Current Trends in Organic Synthesis, 1999, 1).