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Professor Matthew I. Gibson


Prof. Matthew I. Gibson

Professor. Joint between Chemistry and Warwick Medical School.

MChem(Hons) and Ph.D (Dunelm)



Research Summary

We exploit organic, polymer and carbohydrate chemistry to address global healthcare issues, with particular relevance to regenerative medicine and infectious diseases. This covers four main fields: Novel cryoprotectants for biological storage, inspired by antifreeze proteins; Biochemical and thermo-responsive polymers for targeted delivery applications; Materials approaches to glycomics for diagnosis and treament of infection; using synthetic biology to develop methods to remove persistant organic polymers from the environment. The work is highly interdisciplinary and our large and vibrant research group comprises of chemists, biochemists and biologists. We have dedicated facilities synthesis, recombinant protein expression and microbiology as well as analytical lab and cell culture. Professor Gibson is jointly appointed between Chemistry and Warwick Medical School.

Selected Publications

Mitchell, D.E., Clarkson,G., Fox,D.J., Kaner, R.A.,Scott, P., Gibson, M.I., Journal of the American Chemical Society, 2017, Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity. DOI: 10.1021/jacs.7b05822

Mitchell DE., Lovett JR, Armes SP and Gibson MI, Angewandte Chemie, 2016, 55, 2801 - 2804, "Biomimetic Block Copolymer Worms Combined with an Ice-Inhibiting Polymer Enable Solvent-Free Cryopreservation of Red Blood Cells"

Otten, LC, Fullam, E, Gibson, M.I. Molecular Biosystems, 2016, 12, 341 - 344 'Discrimination between Bacterial Species by Ratiometric Analysis of their Carbohydrate Binding Profile

Deller, R.C., Vatish, M., Mitchell, D.A., Gibson, M.I., Nature Communications, 2014, 5, 3244, "Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing"

Jones, MW, Otten, L, Richards, S-J, Lowery, R., Phillips DJ., Haddleton DM., and Gibson MI. Chemical Science. 2014 "Glycopolymers with Secondary Binding Motifs Mimic Glycan Branching and Display Bacterial Lectin Selectivity in Addition to Affinity" Online

Probing Bacterial Toxin Inhibition with Synthetic Glycopolymers using Tandem Post-Polymerization Modification: Role of Linker and Carbohydrate Density. Richards, S-J., Jones, MW, Hunaban, M., Haddleton, DM., Gibson, M.I., Angewandte Chemie. International Edition., 2012, 51, 7812-7816