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Gibson Group: Laura Wilkins


Biography


Laura Wilkins is a PhD student in the Department of Chemistry, funded by the Leverhulme Trust.

Between 2010 and 2014, she carried out her MChem in Chemical Biology at the University of Warwick, completing her final year project in the Gibson Group. This project involved the synthesis of glycopolymers and glyconanoparticles, and an investigation into their biocompatibility.

In the summer holidays after her first and second years, she was awarded bursaries by the Undergraduate Research Scholarship Scheme (URSS) to undertake research jointly in the Clinical Sciences Research Laboratories (UHCW) and Department of Chemistry, supervised jointly by Prof. Donald Singer and Dr. Andrew Marsh. This research investigated the role of calcium-independent phospholipase A2 beta in blood vessel contraction. In the summer of her third year, she worked as a summer research student at Revolymer Ltd. at Deeside Industrial Park.

In 2014-2015, Laura undertook an MSc in Molecular Analytical Science in the MAS CDT at Warwick. During this year, she undertook two analytical miniprojects with Dr. Ann Dixon and Prof. Judith Klein-Seetharam and Dr. Ahmed Eissa and Prof. Neil Cameron respectively.

Previous projects undertaken include:

  • MAS MSc miniproject 2, July - September 2015: Giant (cell-sized) vesicles with tunable rigidity and permeability as carriers in medicine and biotechnology
  • MAS MSc miniproject 1, April-June 2015: The Membrane Receptor Interactome: Prediction and Measurement of Membrane Protein Interaction Networks
  • MChem Research, October 2013 - May 2014: Gluco-functional Polymers/Particles and Study of their Interactions with the GLUT-1 Transporter
  • URSS Research, July – September 2012 and June – September 2011: Pleiotropic regulation of alpha-adrenoceptor-mediated vasoconstriction in human arteries

Research Interests


Laura's PhD is jointly supervised by Matthew Gibson (Department of Chemistry) and Nick Waterfield (Warwick Medical School), funded by the Leverhulme Trust. The project uses a combination of bio-orthogonal chemistry and molecular biology to exploit the function of naturally occurring "molecular syringes".

This research involves:

  • Design, synthesis and analysis of biocompatible glycopolymers by controlled radical polymerisation
  • Bio-orthogonal "click" chemistry
  • Competitive inhibition of toxins for "Anti-adhesion Therapy"
  • Cell targeting for controlled drug delivery and release

Publications

  • [1] Wilkins, LE., Phillips, DJ, Deller, RC, Davies, G-L, Gibson, MI., 'Synthesis and Characterisation of Glucose-Functional Glycopolymers and Gold Nanoparticles: Study of their Potential Interactions with Ovine Red Blood Cells', Carbohydrate Research (Special issue on GlycoNanomaterials), 2015, 405, 47-54. Link.

Oral Presentations

  • June 2015: MOAC DTC Annual Conference, Wilderhope Manor

Poster Presentations

  • June 2017: Warwick Chemistry Postgraduate Symposium, University of Warwick.
  • May 2017: APME 2017, University of Ghent, Belgium.
  • October 2016: RSC Carb 50th Meeting, University of Warwick.
  • July 2016: Warwick Polymers 2016, University of Warwick. "Glycopolymer Anti-infectives against Cholera"
  • June 2015: MOAC DTC Annual Conference, Wilderhope Manor.
  • August 2013: Poster Presentation; 11th European Association of Clinical Pharmacology and Therapeutics Congress, Geneva, Switzerland. "Complex regulation of Alpha-adrenoreceptor-mediated vasoconstriction in human internal thoracic arteries" Related content: Posts by Delegates
  • April 2013: British Microcirculation Society Early Career Investigators Symposium, University of Warwick. "Pleiotropic regulation of alpha-adrenoceptormediated vasoconstriction in human internal mammary arteries".
  • April 2012: 4th BPS Focused Meeting on Cell Signalling, University of Leicester. "Stereoselective and biphasic S-BEL sensitive pathways regulate receptor-mediated but not high-K induced tone in human conduit arteries".

Grants and Bursaries

  • August 2013: European Association for Clinical Pharmacology and Therapeutics (EACPT) and British Pharmacological Society (BPS) travel grants for 11th EACPT Congress 2013, Geneva, Switzerland.
  • April 2012: BPS travel grant for 4th BPS Focused Meeting on Cell Signalling, Leicester 2012.
  • July – September 2012 and June – September 2011: Undergraduate Research Scholarships (research grants awarded), Department of Chemistry, University of Warwick and the Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire (UHCW). Project title: “Pleiotropic regulation of alpha-adrenoceptor-mediated vasoconstriction in human arteries.

Affiliations

  • The Academy of Pharmaceutical Sciences (APS): SAPS Representative for the University of Warwick.
  • Royal Society of Chemistry: Associate membership
  • British Pharmacological Society: Postgraduate Student membership
  • The Biochemical Society: Postgraduate Student membership

Other Interests


UniBrassChamCh

While at the University of Warwick, Laura is an active member of the Brass Society and Chamber Choir. She also regularly climbs in the university's sport centre.

OwlIceland

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EDUCATION


University of Warwick

MSc in Molecular Analytical Science, 2014-2015

MChem in Chemical Biology, 2010-2014


CONTACT


Laura Wilkins
Department of Chemistry
University of Warwick
Gibbet Hill Road
Coventry
CV4 7AL

Email

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