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Gibson Group: Marie Grypioti

Biography


Marie was born in Athens, Greece where she lived until 2009 when she moved to to Heraklion, Crete to undertake her undergraduate studies. During her studies she undertook a three month placement (Oct 2012- Dec 2012) at the University Paul Sabatier under the supervision of Dr Michel Baltas to work on synthesis of InhA inhibitors and their kinetic evaluations. Her final year dissertation project was under the supervision of Prof. Georgios Tsiotis, trying to understand the proteome of the pathogen bacteria Pseudomonas PhDV1. Different separation techniques were used such as SDS- PAGE, native - PAGE, sucrose gradient separation and IEF in liquid phase. The identification of the isolated proteins took place using MALDI ToF - ToF MS.
In 2014 she obtained her master’s degree from Imperial College London. In her master’s thesis she was focusing on a Chemical Biological Study on DOT1L, a protein essential to the emergence of acute leukemia under the supervision of Dr Matthew Fuchter (ICL) and Dr Rachel Grimley (Neusentis, Pfizer).
Before moving to Warwick to start her PhD she spent six months in Toulouse, France, under the supervision of Dr Michel Baltas and Dr Paola Arimondo, to work on potential DNA methyltransferase (DNMT) inhibitors and compounds with biological activities.


Research Interests

The title of my PhD is “Development of tools to understand nutrient uptake at mycobacteria” under the supervision of Dr Elizabeth Fullam and Professor Matthew Gibson. I will be using a chemical biology approach to understand the nutrient uptake and metabolism in Mycobacterium tuberculosis.


Publications

Nawratil S., Grypioti M., Menendez C., Mallet-Ladeira S., Lherbet C. Baltas M. 'Synthesis of a-keto 1,2,3-triazoles through aerobic copper iodide catalyzed oxygenation', European Journal of Organic Chemistry, 2014: 654-659. Link.

Outreach Work

October 2016 Open Day - University of Warwick

March 2017 World TB Day - Cannon Park, Coventry

September 2017 Open Day - University of Warwick

October 2017 New Scientists Live - ExCel, London

Presentations

Oral Presentations:

2015 Midlands Young Researcher Meeting on Nanomaterials - University of Warwick

2017 Molecular Mechanisms Workshop - University of Warwick

Poster Presentations:

In Progress

Affiliations

  • Royal Society of Chemistry: Associate Member (AMRSC)
  • Biochemical Society: Postgraduate Student membership
  • Microbiology: Postgraduate Student membership
  • Association of Greek Chemists: Postgraduate Student membership


Grants and Bursaries


In Progress

Images

grypioti.jpg


Education

Imperial College London

MRes in Drug Discovery and Development: Multidisciplinary Science for Next Generation Therapies, 2013-2014

University of Crete

BSc in Chemistry, 2009-2013

Contact

M.Grypioti@warwick.ac.uk

orcid.org/0000-0002-0802-3341