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Biomolecule-polymer conjugates

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There is great interest in the preparation of biological-synthetic hybrid materials which combine the specficity of biomolecules and the scalability and robustness of polymer constructs. Indeed, DNA and proteins in particular are attractive for conjugation to polymers since they endow synthetic polymers with new function such as recognition and catalysis. In addition, they also give access to a wide range of stimuli-responsive behaviours inaccessible to purely natural-based structures. We are interested in using efficient conjugation routes to allow for the preparation of hybrid materials which can be designed to afford new materials with have enhanced stability and function. We are particularly interested in the conjugation of polymers with,

1. DNA and DNA nanostructures

2. Proteins and enzymes

3. Porphyrins

Selected Publications

Retaining Individualities: the Photodynamics of Self-Ordering Porphyrin Assemblies, W.D. Quan, A. Pitto-Barry, L.A. Baker, E. Stulz, R. Napier, R.K. O'Reilly, V.G. Stavros, Chem. Commun., 2016, 52, 1938-1941 DOI: 10.1039/C5CC09095D

toc135


Self-assembly of temperature-responsive protein-polymer bioconjugates, D. Moatsou, J. Li, A. Ranji, A. Pitto-Barry, I. Ntai, M.C. Jewett, R.K. O'Reilly, Bioconjugate Chem, 2015, 26, 1890-1899. DOI: 10.1021/acs.bioconjchem.5b00264

toc129


Controlled assembly of artificial protein-protein complexes via DNA duplex formation, E. Ploskon, S. Wagner, A. Ellington, M. Jewett, R. O’Reilly, P. Booth, Bioconjugate Chem. 2015, 26, 427–434 DOI: 10.1021/bc500473s

toc121


Construction of DNA–polymer hybrids using intercalation interactions, T. Wilks, A. Pitto-Barry, N. Kirby, E. Stulz, R.K. O'Reilly, Chem Commun, 2014, 50, 1338-1340, DOI:10.1039/C3CC48726A

toc101


'Giant Surfactants' Created by the Fast and Efficient Functionalization of a DNA Tetrahedron with a Temperature-Responsive Polymer, T. Wilks, J. Bath, Jan de Vries, J. Raymond, A. Herrmann, A.J. Turberfield, R.K. O'Reilly, ACS Nano, 2013, 7, 8561-8572. DOI:10.1021/nn402642a

toc96