Wills group research - Organometallic asymmetric catalysis
Recent results in the area of asymmetric catalysis using organometallic catalysts, particularly for asymmetric transfer hydrogenation of ketones and imines. We study the versatility and the kinetics of the reactions, and are always seeking new applications.
For examples of applications of the tethered complexes by other academic groups see:
Su, Y.; Tu, Y-Q.; Gu, P. Org. Lett. 2014, 16, 4204-4207. An application to the synthesis of gamma-lactones via reduction of an in situ-generated ketone.
Mangion, I. K.; Cheng-yi Chen, C.-y.; Li, H.; Maligres, P.; Chen, Y.; Christensen, M.; Cohen, R.; Jeon, I.; Klapars, A.;
Krska, S.; Nguyen, H.; Reamer, R. A.; Sherry, B. D.; Zavialov, I. Org. Lett., 2014, 16, 2310–2313. An application to reduction of a C=NH bond leading to a pharmaceutical target molecule.
For our work see the publications list for the references and more information. Selected examples are shown.
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ref 114
reference 78
reference 82
reference 92
reference 103
reference 97.
reference 80
reference 98
reference 94
references 46 and 71