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Professor Declan Bates

Professor of Bioengineering

 

Co-Director, ESPRC/BBSRC Warwick Integrative Synthetic Biology Centre (WISB)

Co-Director (Warwick), EPSRC/BBSRC Centre for Doctoral Training in Synthetic Biology

Co-Director, Interdisciplinary Collaboration in Systems Medicine

School of Engineering
University of Warwick
Coventry
CV4 7AL, UK

Room: D220
Phone: +44 (0)24 765 23142

D dot Bates at warwick dot ac dot uk

Full CV

 PhD Studentships now available in our group - email me for details

News | Research Interests | Teaching | Publications | Research Grants | Profile

News

  • May 2017: A pre-print of our new paper on cellular resource allocation controllers is now on bioRXiv and is in the top 5% of all research outputs ever tracked by Altmetric.
  • March 2017: Very much looking forward to starting our new £1.4M EPSRC project on “Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications”, in collaboration with our industrial partners Medtronic Ltd. and academic partners Prof. Jonathan Hardman, University of Nottingham, and Dr. Luigi Camporota, King’s College London.
  • January 2017: A nice "Crystal Ball" essay in Microbial Biotechnology from our collaborator Dr. Jose Jimenez of the University of Surrey on the future role of modelling in biology.
  • December 2016: Congratulations to Emzo de los Santos who has been awarded a four-year Research Career Development Fellowship from WISB. We expect great things!
  • November 2016: Our new paper with Marc Chikhani and Jon Hardman from the University of Nottingham is published in the world's leading journal in the field of Anaesthesiology.
  • October 2016: Bon voyage to Rucha Sawlekar who has submitted her PhD thesis exactly 3 years after joining the group and is now departing to take up a PDRA position with Jorge Goncalves' group in Luxembourg. All the best Rucha and we will miss you!
  • September 2016: After a heroic amount of work by Melchior du Lac, our new paper with the Leonard Lab on "Predicting the dynamics and heterogeneity of genomic DNA content within bacterial populations across variable growth regimes" has been accepted for publication in an upcoming special issue of ACS Synthetic Biology on bio-design automation. Congratulations Mel!
  • June 2016: Press release from the University of Nottingham about our new EPSRC Healthcare Grand Challenges Network on Closed Loop Control Systems for Optimisation of Treatment
  • May 2016: Our application to the recent joint BBSRC/NSF call on Synthetic Biology has been selected for funding. We will be working with Prof. Wilson Wong at Boston University for the next three years to develop rewritable biocomputers in mammalian cells.
  • May 2016: Visit to the European Space Agency Headquarters in Holland with Orkun Soyer to discuss future Space applications of Synthetic Biology. Lots of interesting discussions...
  • May 2016: The group has three papers accepted for presentation at the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, to be held in Orlando in August. Congratulations Anup, Wenfei, Rucha, Alex and Mathias.
  • May 2016: Sina Saffaran joins the group to do a PhD in Systems Medicine - welcome Sina!
  • April 2016: WISB Launch Symposium and Industrial Showcase held at Warwick, with keynote speakers Ron Weiss (MIT), Vincent Martin (Concordia) and Judith Armitage (Oxford), and speakers from DNA2.0, Syngenta, Evolva, Ingenza, Shell, Green Biologics, Microsoft Research and Ginkgo Bioworks.
  • November 2015: Rucha Sawlekar was named winner of the 2015 UK Automatic Control Council PhD Showcase - congratulations Rucha!
  • October 2015: Alexander Darlington joins the group to do a PhD in Synthetic Biology, co-supervised by Prof. Orkun Soyer in Life Sciences. Welcome Alex!
  • September 2015: Dr. Emzo de los Santos joins the group, co-supervised by Prof. Greg Challis and Prof. Christophe Corre in Chemistry. Emzo is working on WISB projects on modelling and control of biosynthetic pathways.
  • July 2015: Dr. Mathias Foo joins the group, working on WISB projects on synthetic control systems and plant re-engineering.
  • May 2015: The group has 4 papers accepted for presentation at the 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, taking place in Milan this August - congratulations everyone!
  • May 2015: Dr. Jamie Luo joins the group, co-supervised by Dr. Sara Kalvala in Computer Science. Jamie is a WISB researcher working on the development of modelling and design tools for synthetic microbial communities.
  • June 2015: Jack, Rucha and Mel present their research at the Synthetic Biology: Engineering, Evolution and Design (SEED) conference in Boston.
  • January 2015: Prof. Vishwesh Kulkarni joins the School of Engineering at Warwick as Assistant Professor of Synthetic Biology - welcome Vishwesh!
  • January 2015: Secretary of State for Business, Innovation and Skills, Vince Cable, announces that researchers at the Warwick Integrative Synthetic Biology centre (WISB) have been awarded a five-year £12.4 million research grant. More info. Coverage in The Guardian
  • January 2015: Our new paper in Critical Care is Highly Accessed
  • December 2014: 15 PDRA positions available in WISB - more info.
  • November 2014: Oxford-Warwick-Bristol Centre for Doctoral Training in Synthetic Biology is now accepting applications for 2015/2016 - applications from engineering students are particularly welcome! More info.
  • August 2014: New video with Rainbow Seed Fund on Synthetic Biology now on Youtube
  • August 2014: Our work is featured at a Mini-Symposium on Advanced Engineering in Respiratory Medicine, organised by Phillips Research North America at the 36th Annual IEEE Engineering in Medicine and Biology Society Conference in Chicago
  • July 2014: We have contributed two chapters to the new book "A Systems Theoretic Approach to Systems and Synthetic Biology" edited by Vishwesh Kulkarni, Guy-Bart Stan and Karthik Raman, and published by Springer
  • June 2013: TEDx talk on Systems Medicine now on Youtube

Research Interests

  • Systems Medicine
    • Pulmonary and cardiovascular pathophysiology

    • Mechanical ventilation of critically ill patients

    • Personalised simulation and control technologies for the Intensive Care Unit

  • Synthetic Biology
    • Systems and control theory for synthetic biology

    • Modelling and simulation frameworks for robust model-based design of synthetic biological systems

    • Design of synthetic circuits using recombinases and DNA-based chemistry

For papers and research grants related to my previous research on Aerospace Control, click here


Teaching


Recent Publications

  • W. Wang, A. Das, W. Schmitt, J.G. Hardman, G. Weimann and D.G. Bates, "An inhaled sGC modulator can lower PH in COPD patients without deteriorating oxygenation", submitted, 2017.
  • A.P.S. Darlington, J. Kim, J.I. Jimenez, and D.G. Bates, "Dynamic Allocation Of Orthogonal Ribosomes Facilitates Uncoupling Of Co-Expressed Genes", submitted. Preprint available on BioRXiv: pdf
  • M. Foo, J. Kim, and D.G. Bates, "Modelling and Control of Gene Regulatory Networks for Perturbation Mitigation", submitted.
  • J. Bowyer, E.L.C. de los Santos, K.M. Styles, C. Corre and D.G. Bates, "Modeling the Architecture of the Regulatory System Controlling Methylenomycin Production in Streptomyces coelicolor", submitted.
  • D.O.A. Alowa, T.A. Tahir, M. Fischer, D.G. Bates, S. Amirova and N.P.J. Brindle, "Regulation of Angiopoietin Signalling by Endogenous Soluble Tie2 Ectodomain and Engineered Ligand Trap", to appear in Scientific Reports, 2017.
  • J.E. Bowyer, V. Hsiao, W.W. Wong and D.G. Bates, "Mechanistic modelling of a recombinase-based two-input temporal logic gate", to appear in IET Engineering Biology, 2017.
  • M. Laviola, A. Das, M. Chikhani, D.G. Bates and J.G. Hardman "Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computational simulation", to appear in proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, JeJu Island, S. Korea, 2017.
  • S. Saffaran, A. Das, J.G. Hardman, N. Yehya, and D.G. Bates, "Development and Validation of a Computational Simulator for Pediatric ARDS Patients", to appear in proceedings of the 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, JeJu Island, S. Korea, 2017.
  • M. Foo, I. Gherman, K. Denby and D.G. Bates, "Control Strategies for Mitigating the Effect of External Perturbations on Gene Regulatory Networks", to appear in proceedings of the 20th World Congress of the International Federation of Automatic Control (IFAC), Toulouse, 2017.
  • M. Foo, J. Kim and D.G. Bates, "System identification of gene regulatory networks for perturbation mitigation via feedback control", to appear in proceedings of the 14th IEEE International Conference on Networking, Sensing and Control, Calabria, 2017.
  • A. Das, M. Haque, M. Chikhani, O. Cole, W. Wang, J.G. Hardman and D.G. Bates, "Hemodynamic effects of lung recruitment maneuvers in acute respiratory distress syndrome", BMC Pulmonary Medicine, 17:34,

    DOI: 10.1186/s12890-017-0369-7, 2017. pdf

  • M. Foo, J. Kim, R. Sawlekar and D.G. Bates, "Embedded inverse-feedforward tracking control of enzymatic reaction processes", Computers & Chemical Engineering, 99, 145–157, DOI: 10.1016/j.compchemeng.2017.01.027, 2017. pdf
  • M. Foo, J. Kim, J. Kim and D.G. Bates, "Proportional-Integral Degradation (PI-Deg) control allows accurate tracking of biomolecular concentrations with fewer chemical reactions", IEEE Life Sciences Letters, 2(4), DOI: 10.1109/LLS.2016.2644652, 2016. pdf
  • M. Foo, R. Sawlekar and D.G. Bates, "Exploiting the dynamic properties of covalent modification cycles for the design of synthetic analog circuitry", Journal of Biological Engineering, 10:15, DOI: 10.1186/s13036-016-0036-1, 2016. pdf
  • M. Chikhani, A. Das, M. Haque, W. Wang, D.G. Bates, and J.G. Hardman, "High PEEP in ARDS: evaluating the trade-off between improved oxygenation and decreased oxygen delivery", British Journal of Anaesthesia, 117 (5): 650–8 (2016) DOI: 10.1093/bja/aew314, 2016. pdf
  • J. Bowyer, V. Hsiao and D.G. Bates, "Development and Experimental Validation of a Mechanistic Model of a Recombinase-Based Temporal Logic Gate", in proceedings of the 12th IEEE Biomedical Circuits and Systems Conference, Shanghai, 2016. pdf
  • R. Sawlekar, M. Foo and D.G. Bates, "Robustness Analysis of DNA-based Biomolecular Feedback Controllers to Parametric and Time Delay Uncertainties", in proceedings of the 12th IEEE Biomedical Circuits and Systems Conference, Shanghai, 2016. pdf
  • M. du Lac, A. Scarpelli, A.K.D. Younger, D.G Bates and J. Leonard, "Predicting the dynamics and heterogeneity of genomic DNA content within bacterial populations across variable growth regimes", ACS Synthetic Biology, Special Issue on Bio-Design Automation, DOI: 10.1021/acssynbio.5b00217, 2016. pdf
  • M. Bilotta, C. Cosentino, A. Merola, D.G. Bates and F. Amato, "Zero-Retroactivity Subtraction Module for Embedded Feedback Control of Chemical Reaction Networks", in proceedings of the 6th IFAC Conference on Foundations of Systems Biology in Engineering, Magdeburg, 2016. pdf
  • F. Montefusco, O. Akman, O. Soyer and D.G. Bates, "Ultrasensitive Negative Feedback Control: A Natural Approach for the Design of Synthetic Controllers", PloS One 11(8):e0161605, doi:10.1371/journal.pone.0161605, 2016. pdf
  • M. Foo, R. Sawlekar, V.V. Kulkarni and D.G. Bates, "Biologically inspired design of feedback control systems implemented using DNA strand displacement reactions", in proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, 2016. pdf
  • A. Darlington and D.G. Bates, "Host-aware modelling of a synthetic genetic oscillator", in proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, 2016. pdf
  • A. Das, M. Haque, M. Chikhani, W. Wang, J.G. Hardman and D.G. Bates, "Creating Virtual ARDS Patients", in proceedings of the 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Orlando, 2016. pdf
  • M. Foo, R. Sawlekar, J. Kim, G.-B. Stan, D.G. Bates and V.V. Kulkarni, "On the biomolecular implementation of nonlinear system theoretic operators", in the Proceedings of the European Control Conference, Aalborg, 2016. pdf
  • R. Sawlekar, F. Montefusco, V.V. Kulkarni and D.G. Bates, "Implementing Nonlinear Feedback Controllers using DNA Strand Displacement Reactions", IEEE Transactions on NanoBioscience, DOI: 10.1109/TNB.2016.2560764, 2016. pdf
  • J. Bowyer, J. Zhao, P. Subsoontorn, W. Wong, S. Rosser and D.G. Bates, "Mechanistic Modeling of a Rewritable Recombinase Addressable Data Module", IEEE Transactions on Biomedical Circuits and Systems, 10(6), 1161-1170, DOI: 10.1109/TBCAS.2016.2526668, 2016. pdf
  • A. Steinacher, D.G. Bates, O. Akman and O. Soyer, "Nonlinear Dynamics in Gene Regulation Promote Robustness and Evolvability of Gene Expression Levels", PLoS ONE 11(4): e0153295. doi:10.1371/journal.pone.0153295, 2016. pdf
  • W. Wang, A. Das, O. Cole, M. Chikhani, J.G. Hardman and D.G. Bates, "Computational simulation indicates that moderately high frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients", Intensive Care Medicine Experimental 3(1), 1-12, 2015. pdf
  • R. Sawlekar, F. Montefusco, V.V. Kulkarni and D. G. Bates, "Biomolecular Implementation of a Quasi Sliding Mode Feedback Controller based on DNA Strand Displacement Reactions", in Proceedings of the 37th IEEE Engineering in Medicine and Biology Conference, Milano, 2015. pdf
  • J. Bowyer, J. Zhao, S. Rosser, S. Colloms and D.G. Bates, "Development and Experimental Validation of a Mechanistic Model of in vitro DNA Recombination", in Proceedings of the 37th IEEE Engineering in Medicine and Biology Conference, Milano, 2015. pdf
  • A. Das, M. Haque, M. Chikhani, W. Wang, T. Ali, O. Cole, J.G. Hardman and D.G. Bates, "Development of an Integrated Model of Cardiovascular and Pulmonary Physiology for the Evaluation of Mechanical Ventilation Strategies", in Proceedings of the 37th IEEE Engineering in Medicine and Biology Conference, Milano, 2015. pdf
  • M. Bilotta, C. Cosentino, D.G. Bates and F. Amato, "Retroactivity Analysis of a Chemical Reaction Network Module for the Subtraction of Molecular Fluxes", in Proceedings of the 37th IEEE Engineering in Medicine and Biology Conference, Milano, 2015. pdf
  • A. Das, O. Cole, M. Chikhani, W. Wang, T. Ali, M. Haque, J.G. Hardman and D.G. Bates, "Evaluation of lung recruitment maneuvers in Acute Respiratory Distress Syndrome using computer simulation", Critical Care, 19:8, doi:10.1186/s13054-014-0723-62014, 2015. pdf
  • W. Wang, P.P. Menon, D.G. Bates, S. Ciabuschi, N.M. Gomes Paulino, E. Di Sotto, A. Bidaux, A. Kron, S. Salehi, S. Bennani, "Verification and Validation Framework for Autonomous Rendezvous Systems in the Terminal Phase", AIAA Journal of Spacecraft and Rockets, doi: 10.2514/1.A32531, 2014. pdf
  • W. Wang, A. Das, T. Ali, O. Cole, M. Chikhani, M. Haque, J.G. Hardman and D.G. Bates, "Can computer simulators accurately represent the pathophysiology of individual COPD patients?", Intensive Care Medicine Experimental, 2:23, doi:10.1186/s40635-014-0023-02014, 2014. pdf
  • F. Montefusco, O.E. Akman, O.S. Soyer, and D.G. Bates, "Modelling and Analysis of Feedback Control Mechanisms Underlying Osmoregulation in Yeast", in A Systems Theoretic Approach to Systems and Synthetic Biology, Editors: V.V. Kulkarni, G.-B. Stan and K. Raman, 2014. pdf
  • J. Kim, M. Kishida and D.G. Bates, "State bounds estimation for nonlinear systems using mu-analysis", in Proceedings of the 19th World Congress of the International Federation of Automatic Control, Cape Town, South Africa. August 24-29, 2014. pdf
  • L. Salerno, C. Cosentino, A. Merola, D.G. Bates and F. Amato, “Validation of a model of the GAL regulatory system via robustness analysis of its bistability characteristics”, BMC Systems Biology, 17;7(1):39, 2013. pdf
  • A.Das, P.P. Menon, J. Hardman and D.G. Bates, “Optimization of Ventilation Settings for Pulmonary Disease States”, IEEE Transactions on Biomedical Engineering, 60(6):1599-607, 2013. pdf
  • F. Montefusco, A. Steinacher, O. Akman, D.G. Bates and O.S. Soyer, “On the Role of Ultrasensitivity in Biomolecular Control Systems”, Invited Session on Control Theory for Synthetic Biology, in Proceedings of the IEEE Conference on Decision and Control, Hawaii, 2012. pdf
  • C. Cosentino, L. Salerno, A. Passanti, A. Merola, D.G. Bates, F. Amato, “Structural bistability of the GAL regulatory network and characterization of its domains of attraction”, Journal of Computational Biology, 19(2):148-62, 2012. pdf
  • C. Cosentino and D.G. Bates, Feedback Control in Systems Biology, CRC Press (Taylor & Francis), 2011.
  • F. Montefusco, C. Cosentino, F. Amato and D.G. Bates, “Reverse-Engineering Biological Interaction Networks from Noisy Data using Regularized Least Squares and Instrumental Variables”, Proceedings of the joint IEEE Conference on Decision and Control / European Control Conference, Orlando, Florida, 2011. pdf
  • N. Kotov, D.G. Bates et al, “Computational modelling elucidates the mechanism of ciliary regulation in health and disease”, BMC Systems Biology 5:143, 2011. pdf
  • D.G. Bates and C. Cosentino, “Validation and Invalidation of Systems Biology Models using Robustness Analysis”, IET Systems Biology, 5(4)229-244, 2011. pdf
  • F. Montefusco, C. Cosentino and D.G. Bates, “Introduction to network reconstruction methods based on dynamical systems theory”, in Handbook of Statistical Systems Biology, M. Stumpf, D.J. Balding, M. Girolami (Eds.), Wiley, 2011. pdf
  • C. Rato, S. Amirova, D.G. Bates, I. Stansfield and H.M. Wallace, “Translational recoding as a feedback controller: systems approaches reveal polyamine-specific effects on the antizyme ribosomal frameshift”, Nucleic Acids Research, doi:10.1093/nar/gkq1349, 2011. pdf
  • A. Das, Z. Gao, P.P. Menon, J. Hardman and D.G. Bates, “A Systems Engineering approach to validation of a pulmonary physiology simulator for clinical applications”, Journal of The Royal Society Interface, doi: 10.1098/rsif.2010.0224, 2011. pdf
  • J. Kim, P. Heslop-Harrison, I. Postlethwaite and D. G. Bates, “Structural adaptation and robustness of Dictyostelium ligand-receptor kinetics for low and high ligand concentration”, International Journal of Robust and Nonlinear Control, Special Issue: Focus on Robustness in Systems Biology: Methods and Applications, 20(9): 1047-1058, 2010. pdf
  • J.-S. Kim, N. V. Valeyev, I. Postlethwaite, P. Heslop-Harrison, K.-W. Cho and D. G. Bates, “Analysis and Extension of a Biochemical Network Model Using Robust Control Theory”, International Journal of Robust and Nonlinear Control, Special Issue: Focus on Robustness in Systems Biology: Methods and Applications, 20(9): 1017-1026, 2010. pdf
  • C.-Y. Dong, T.-W. Yoon, D. G. Bates and K.-H. Cho, “Identification of Feedback Loops Embedded in Cellular Circuits by Investigating Non-Causal Impulse Response Components”, Journal of Mathematical Biology, DOI: 10.1007/s00285-009-0263-x, 2009. pdf
  • N. V. Valeyev, J.-S. Kim, P. Heslop-Harrison, I. Postlethwaite, N. Kotov and D. G. Bates, “Computational Modelling Suggests Dynamic Interactions between Ca2+, IP3 and G Protein-Coupled Modules are Key to Achieving Robust Dictyostelium Aggregation”, Molecular BioSystems, Vol. 5, 612-628, 2009. pdf
  • N. V. Valeyev, N. Kotov, P. Heslop-Harrison, I. Postlethwaite and D. G. Bates, “Crosstalk between G-protein and Ca2+ pathways switches intracellular cAMP levels”, Molecular BioSystems, Vol. 5(1), 2008. pdf
  • J. Kim, D. G. Bates and I. Postlethwaite, “Evaluation of Stochastic Effects on Biomolecular Networks using the Generalised Nyquist Stability Criterion”, IEEE Transactions on Automatic Control, Vol. 53(8), 2008. pdf

Current/Recent Research Grants

  • £59.7K, Investigation of Closed-Loop Ventilation Strategies for Neonatal ICU Patients using Computational Simulation, EPSRC Healthcare Technologies Network Plus Feasibility Study, (with Prof. Don Sharkey and Prof. Jonathan Hardman, University of Nottingham), 2017-2018
  • £1.4M, Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications, EPSRC and Medtronic Ltd., with Prof. Jonathan Hardman, University of Nottingham, and Dr. Luigi Camporota, King’s College London, 2017-2021
  • £298K/$665K, Rewritable Biocomputers in Mammalian Cells, BBSRC/NSF, (with Prof. Wilson Wong, University of Boston), 2017-2020
  • £634K, Closed Loop Control Systems for Optimisation of Treatment, EPSRC Healthcare Technologies Network Plus Grant, (with Prof. Steve Morgan and Prof. Jonathan Hardman, University of Nottingham, and Prof. Helen Byrne, University of Oxford), 2016-2019
  • £220K, Development of a Computational Simulator, Bayer Healthcare Commercial Research Contract, 2015-2017
  • £12.4M, Warwick Integrative Synthetic Biology Centre, BBSRC/EPSRC, (with Prof. John McCarthy and Prof. Orkun Soyer, University of Warwick), 2015-2020
  • £4.7M, Centre for Doctoral Training in Synthetic Biology, EPSRC/BBSRC, (with Prof. Antonis Papachristodoulou, Prof. Andrew Tuberfield, Prof. Judy Armitage, University of Oxford, Prof. Claire Grierson, Prof. Dek Wolfson, University of Bristol, Prof. Orkun Soyer, University of Warwick), 2014-2022.
  • £1.4M, Exploiting the Syntegron Technology Platform for Assembly and Optimisation of Complex Genetic Ensembles, EPSRC/NSF, (with Prof. Susan Rosser, University of Glasgow, Prof. Paul Freemont, Imperial College London, Prof. Anne Osbourn, John Innes Centre, Prof. Joshua Leonard, Northwestern University, USA and Prof. Jay Keasling, University of Berkeley, USA) 2013-2016.
  • £650K, Integrated Cardiopulmonary Modelling for the Investigation of the Management of Disturbed Tissue Perfusion, MRC, (with Prof. Jonathan Hardman and Dr. Iain Moppett, University of Nottingham), 2012-2015.
  • £4M, Engineering Synthetic Microbial Communities for Biomethane Production, BBSRC sLOLA, (with Prof. Orkun Soyer, School of Life Sciences, University of Warwick, Prof. Richard Titball, Prof. David Studholme and Prof. Angus Buckling, University of Exeter, Prof. Russell Davenport, Prof. Jan Dolfing and Prof. Tom Curtis, University of Newcastle, David Campbell Stuckey, Imperial College London, Prof. David Swarbreck, TGAC), 2013-2018.
  • £425K, Development, Validation and Application of Population-Based Pulmonary Disease Models using Robustness Analysis and Ensemble Forecasting, EPSRC, (with Prof. Jonathan Hardman, Queen’s Medical Centre, University of Nottingham), 2011-2014.
  • £417K, Evolving Controllers and Controlling Evolution, EPSRC (with Prof. Orkun Soyer, School of Life Sciences, University of Warwick), 2011-2014.
  • £1.4M, Synthetic Integrons for Continuous Directed Evolution of Complex Genetic Ensembles, EPSRC/NSF, (with Dr. Susan Rosser, University of Glasgow, Prof. Paul Freemont, Imperial College London, Prof. Anne Osbourn, John Innes Centre, Prof. Joshua Leonard, Northwestern University, USA and Prof. Jay Keasling, University of Berkeley, USA) 2010-2012.
  • £586, Post-Transcriptional Feedback Control of Polyamine Metabolism in Yeast: An Integrated Modelling and Experimental Investigation, BBSRC, (with Dr. Ian Stansfield, University of Aberdeen), 2008-2011.
  • £432K, Preventing Ventilator Associated Lung Injury using Feedback Control Engineering, EPSRC, (with Dr. Jonathan Hardman, University of Nottingham), 2008-2011.

Profile

Declan Bates is Professor of Bioengineering in the School of Engineering at the University of Warwick. He is Co-Director of the BBSRC/EPSRC Warwick Integrative Synthetic Biology Centre (WISB), and Co-Director at Warwick of the EPSRC/BBSRC Oxford-Warwick-Bristol Centre for Doctoral Training in Synthetic Biology.

 
Prof. Bates was born in Clonmel, Co. Tipperary, Ireland in 1970 and educated at Powerstown National School and the High School, Clonmel. He received a B.Eng degree in Electronic Engineering and a Ph.D. degree in Robust Control Theory from the School of Electronic Engineering, Dublin City University, Ireland, in 1992 and 1996 respectively. On completing his PhD he joined the Control and Instrumentation Research Group led by Prof. Ian Postlethwaite in the Department of Engineering at Leicester University, where he worked as a post-doctoral research associate, lecturer, and senior lecturer, before being appointed to a Personal Chair in Control Engineering, aged 38. In 2010 he was appointed Professor of Biological Systems Engineering in the College of Engineering, Mathematics and Physical Sciences of the University of Exeter and in 2013 he moved to the University of Warwick as Professor of Bioengineering.

His early research applied design and analysis methods from robust control theory to a range of aersopace systems, including gas-turbine engines (with Alstom Power) and large passenger aircraft (with Airbus). Between 2007 and 2012 his group participated in nine research projects funded by the European Space Agency. Working with industrial partners including GMV, Deimos Space, Alenia Thales and Astrium, these projects developed advanced verification and validation methods for applications ranging from hypersonic re-entry vehicles, launch vehicles, flexible satellites and autonomous rendezvous systems.

His current research is focussed on the modelling, analysis, design and control of complex biological and medical systems. In 2006, he was awarded an EPSRC Discipline Hopping Research Fellowship with Prof. Jonathan Hardman of the Queen's Medical Centre of the University of Nottingham to pursue research on the Control Engineering/Life Sciences Interface. From 2007 to 2010, he was a member of BBSRC's Engineering and Biological Systems Research Committee, and subsequently a core member of BBSRC's Research Committee C on Technology and Methodological Development. From 2009 to 2014, he was a member, Co-Chair and subsequently Chair of the Research Grants Review Committee of the International Human Frontier Science Program. He is currently a member of EPSRC’s Peer Review College and Chair of the HFSP review committee for Career Development Awards. He is the co-author (with Carlo Cosentino) of Feedback Control in Systems Biology, published by Taylor & Francis. He has authored more than 150 peer reviewed research publications and obtained funding in excess of £10M from EPSRC, BBSRC, MRC, ESA and industry.

photo


Current Postdoctoral Research Associates:

Dr. Anup Das

Dr. Mathias Foo

Dr. Jack Bowyer

Dr. Emzo de los Santos (WISB Research Career Development Fellow)


Current PhD students:

Melchior du Lac

Alexander Darlington

Iulia Ghermain

Sina Saffaran

 

Book

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