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Biomaterials, Tissue Engineering and Regenerative Medicine

(15 Credits)

Aims:

The module will provide the students with a sound understanding of biomaterials and their use in biomedical applications. A range of topics will be explored, including biocompatibility and the foreign body response, interfacial properties of biomaterials, and factors affecting cellular response and protein adsorption. Polymers and ceramics used in medicine are reviewed with examples including the total hip joint replacement (TFJR), heart valves, catheters and vascular grafts and hydrogels used in ophthalmology. Contemporary topics in biomaterials will be covered, such as nanobiomaterials, nanomedicine, drug delivery, tissue engineering and regenerative medicine.

Learning Outcomes:

At completion, students will be able to:
• Understand the complex processes involved in biocompatibility and protein adsorption, and the importance of surfaces in advanced biomaterials applications.
• Understand the different classes of modern biomaterials used in the body and be able to critically evaluate materials appropriately for a given application.
• Understand nanomedicine and advanced drug delivery, and the action and use of cutting-edge smart biomaterials.
• Understand and be able to apply modern techniques used to modify, characterise and systematically evaluate biomaterial surfaces.
• Understand state-of-the-art techniques used in tissue engineering, including methods of scaffold manufacture. Be able to critically assess tissue engineering methods for a given scenario.
• Understand the basic principles of stem cell biology, including its applications, and the importance of TERM.

Illustrative Bibliography

- Biomaterials Science: An Introduction to Materials in Medicine (3rd ed.), Ed. Buddy D. Ratner, et al., Elsevier, 2013.
- Principles of Tissue Engineering (3rd ed.), Ed. Robert P. Lanza, Robert Langer, Joseph Vacanti, Elsevier, 2007.