Professor Mark Wall
Professor
Email: Mark.Wall@warwick.ac.uk
Phone: 024 765 73772
Office: IBRB 1.27
Research Clusters
Vacancies and Opportunities
For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Research Interests
I am a neuroscientist interested in measuring the electrical properties of neurons in the mammalian brain and how they change in conditions such as epilepsy, schizophrenia, and Alzheimer’s disease.
Research: Technical Summary
I am an electrophysiologist interested in neuronal and synaptic physiology in both health and disease. I use extracellular recording, FSCV and multiple patch-clamp recording to study synaptic transmission and the properties of neurons. I combine electrophysiology with computational analysis (in collaboration with Prof Magnus Richardson Warwick Mathematics) to measure the electrophysiological properties of neurons.
Current projects include investigation of neuronal function in models of epilepsy, schizophrenia, and neurodegeneration (AD and PD) and how neural circuits can be modulated by changes in the levels of carbon dioxide.
- PhD Neurophysiology. Department of Zoology, University of Bristol 1993
- Brown, Jessica, Camporesi, Elena, Lantero-Rodriguez, Juan, Olsson, Maria, Wang, Alice, Medem, Blanca, Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K., Wall, Mark J., Hill, Emily, 2023. Tau in cerebrospinal fluid induces neuronal hyperexcitability and alters hippocampal theta oscillations. Acta Neuropathologica Communications, 11
- Haley, Maisy, Bertrand, Jeanri, Anderson, Vanessa Torrico, Fuad, Mukattar, Frenguelli, Bruno G., Corrêa, Sônia A. L., Wall, Mark J., 2023. Arc expression regulates long-term potentiation magnitude and metaplasticity in area CA1 of the hippocampus in ArcKR mice. European Journal of Neuroscience, 58 (10), pp. 4166-4180
- 'Brown, Jessica, 'Iacovelli, Luisa, 'Di Cicco, Gabriele, 'Grayson, Ben, 'Rimmer, Lauren, 'Fletcher, Jennifer, 'Neill, Joanna C., 'Wall, Mark J., 'Ngomba, Richard T., 'Harte, Michael, 2022. 'The comparative effects of mGlu5 receptor positive allosteric modulators VU0409551 and VU0360172 on cognitive deficits and signalling in the sub-chronic PCP rat model for schizophrenia. Neuropharmacology, 208
- 'Privitera, Lucia, 'Hogg, Ellen L., 'Lopes, Marcia, 'Domingos, Luana B., 'Gaestel, Matthias, 'Müller, Jürgen, 'Wall, Mark J., 'Corrêa, Sônia A. L., 2022. 'The MK2 cascade mediates transient alteration in mGluR-LTD and spatial learning in a murine model of Alzheimer?s disease. Aging Cell
- Wall, Mark J., Puddefoot, Katie, Yin, Wencheng, Bingham, Chris, Seifi, Mohsen, Swinny, Jerome D., Teke Ngomba, Richard, 2022. Adenosine is released during thalamic oscillations to provide negative feedback control. Neuropharmacology, 216
- Wall, Mark J., Hill, Emily, Huckstepp, Robert T. R., Barkan, Kerry, Deganutti, Giuseppe, Leuenberger, Michele, Preti, Barbara, Winfield, Ian, Carvalho, Sabrina, Suchankova, Anna, Wei, Haifeng, Safitri, Dewi, Huang, Xianglin, Imlach, Wendy, La Mache, Circe, Dean, Eve, Hume, Cherise, Hayward, Stephanie, Oliver, Jess, Zhao, Fei-Yue et al (Select to open full list), 2022. Selective activation of G?ob by an adenosine A 1 receptor agonist elicits analgesia without cardiorespiratory depression. Nature Communications, 13 (1)
- Deganutti, Giuseppe, Barkan, Kerry, Preti, Barbara, Leuenberger, Michele, Wall, Mark J., Frenguelli, Bruno G., Lochner, Martin, Ladds, Graham, Reynolds, Christopher A., 2021. Deciphering the agonist binding mechanism to the adenosine A1 receptor. ACS Pharmacology & Translational Science, 4 (1), pp. 314-326
- Di Cicco, Gabriele, Marzano, Emanuela, Iacovelli, Luisa, Celli, Roberta, van Luijtelaar, Gilles, Nicoletti, Ferdinando, Ngomba, Richard T., Wall, Mark J., 2021. Group I metabotropic glutamate receptor-mediated long term depression is disrupted in the hippocampus of WAG/Rij rats modelling absence epilepsy. Neuropharmacology, 196
- Hill, Emily, Karikari, Thomas K., Lantero-Rodriguez, Juan, Zetterberg, Henrik, Blennow, Kaj, Richardson, Magnus J. E., Wall, Mark J., 2021. Truncating Tau reveals different pathophysiological actions of oligomers in single neurons. Communications Biology, 4
- Hill, Emily, Dale, Nicholas, Wall, Mark J., 2021. CO2-sensitive connexin hemichannels in neurons and glia : three different modes of signalling?. International Journal of Molecular Sciences, 22 (14)
- Celli, Roberta, Wall, Mark J., Santolini, Ines, Vergassola, Matteo, Di Menna, Luisa, Mascio, Giada, Cannella, Milena, van Luijtelaar, Gilles, Pittaluga, Anna, Ciruela, Francisco, Bruno, Valeria, Nicoletti, Ferdinando, Ngomba, Richard T., 2020. Pharmacological activation of mGlu5 receptors with the positive allosteric modulator, VU0360172 modulates thalamic GABAergic transmission. Neuropharmacology, 178
- Hill, Emily, Dale, Nicholas, Wall, Mark J., 2020. Detecting CO2-sensitive hemichannels in neurons in acute brain slices. STAR Protocols, 1 (3)
- Hill, Emily, Hickman, Charlotte, Diez, Rebecca, Wall, Mark J., 2020. Role of A1 receptor-activated GIRK channels in the suppression of hippocampal seizure activity. Neuropharmacology, 164
- Hill, Emily, Dale, Nicholas, Wall, Mark J., 2020. Moderate changes in CO2 modulate the firing of neurons in the VTA and substantia nigra. iScience, 23 (7)
- Hill, Emily, Gowers, Robert, Richardson, Magnus J. E., Wall, Mark J., 2020. Alpha-synuclein aggregates increase the conductance of substantia nigra dopamine neurons, an effect partly reversed by the KATP channel inhibitor glibenclamide. eNeuro, pp. ENEURO.0330-20.2020
- Hill, Emily, Wall, Mark J., Moffat, Kevin G., Karikari , T., 2020. Understanding the pathophysiological actions of tau oligomers : a critical review of current electrophysiological methods. Frontiers in Molecular Neuroscience, 13
- Privitera, Lucia, Hogg, Ellen L., Gaestel, Matthias, Wall, Mark J., Corrêa, Sônia A. L., 2019. The MK2 cascade regulates mGluR-dependent synaptic plasticity and reversal learning. Neuropharmacology, 155, pp. 121-130
- Hill, Emily, Karikaria, Thomas K., Moffat, Kevin G., Richardson, Magnus J. E., Wall, Mark J., 2019. Introduction of tau oligomers into cortical neurons alters action potential dynamics and disrupts synaptic transmission and plasticity. eNeuro, 6 (5)
- Wall, Mark J., Corrêa, Sônia A. L., 2018. The mechanistic link between Arc/Arg3.1 expression and AMPA receptor endocytosis. Seminars in Cell and Developmental Biology, 77, pp. 17-24
- Hills, Claire E., Price, G. W., Wall, Mark J., Kauffman, T. J., Tang, S. C., Yiu, W. H., Squires, P. E., 2018. Transforming growth Factor Beta 1 drives a switch in connexin mediated cell-to-cell communication in tubular cells of the diabetic kidney. Cellular Physiology and Biochemistry, 45 (6), pp. 2369-2388
- Wall, Mark J., Collins, Dawn R., Chery, Samantha L., Allen, Zachary D., Pastuzyn, Elissa D., George, Arlene J., Nikolova, Viktoriya D., Moy, Sheryl S., Philpot, Benjamin D., Shepherd, Jason D., Müller, Jürgen, Ehlers, Michael D., Mabb, Angela M., Corrêa, Sônia A. L., 2018. The temporal dynamics of Arc expression regulate cognitive flexibility. Neuron, 98 (6), pp. 1124-1132
- Hughes, Victoria, Richardson, Magnus J. E., Wall, Mark J., 2018. Acute ethanol exposure has bidirectional actions on the endogenous neuromodulator adenosine in rat hippocampus. British Journal of Pharmacology, 175 (9), pp. 1471-1485
- Diez, Rebecca, Richardson, Magnus J. E., Wall, Mark J., 2017. Reducing extracellular Ca2+ induces adenosine release via equilibrative nucleoside transporters to provide negative feedback control of activity in the hippocampus. Frontiers in Neural Circuits, 11
- Newton, Adam J. H., Wall, Mark J., Richardson, Magnus J. E., 2017. Modelling microelectrode biosensors : free-flow calibration can substantially underestimate tissue concentrations. Journal of Neurophysiology, 117 (3), pp. 937-949
- Bird, Alex D., Wall, Mark J., Richardson, Magnus J. E., 2016. Bayesian inference of synaptic quantal parameters from correlated vesicle release. Frontiers in Computational Neuroscience, 10
- Frenguelli, Bruno G., Wall, Mark J., 2016. Combined electrophysiological and biosensor approaches to study purinergic regulation of epileptiform activity in cortical tissue. Journal of Neuroscience Methods, 260, pp. 202-214
- DaSilva, Luis L., Wall, Mark J., Almeida, Luciana P. de, Wauters, Sandrine, Januario, Yunan C., Müller, Jürgen, Corrêa, Sônia A. L., 2016. Arc controls AMPAR endocytosis through a direct interaction with clathrin-adaptor protein 2. eNeuro, 3 (3)
- Kaufmann, Timothy J., Harrison, Paul Michael, Richardson, Magnus J. E., Pinheiro, Teresa J. T., Wall, Mark J., 2016. Intracellular soluble a-synuclein oligomers reduce pyramidal cell excitability. The Journal of Physiology, 594 (10), pp. 2751-2772
- Wall, Mark J., Richardson, Magnus J. E., 2015. Localised adenosine signalling provides fine-tuned negative feedback over a wide dynamic range of neocortical network activities. Journal of Neurophysiology, 113 (3), pp. 871-882
- Harrison, Paul Michael, Badel, Laurent, Wall, Mark J., Richardson, Magnus J. E., 2015. Experimentally verified parameter sets for modelling heterogeneous neocortical pyramidal-cell populations. PLoS Computational Biology, 11 (8), pp. 1-23
- Mabb, Angela M., Je, H. Shawn, Wall, Mark J., Robinson, Camenzind G., Larsen, Rylan S., Qiang, Yuan, Corrêa, Sônia A. L., Ehlers, Michael D., 2014. Triad3A regulates synaptic strength by ubiquitination of Arc. Neuron, 82 (6), pp. 1299-1316
- Hills, Claire E., Kerr, Michael I., Wall, Mark J., Squires, Paul E., 2013. Visfatin reduces gap junction mediated cell-to-cell communication in proximal tubule-derived epithelial cells. Cellular Physiology & Biochemistry, 32 (5), pp. 1200-1212
- Thomas, M. G., Covington, James A., Wall, Mark J., 2013. A chamber for the perfusion of in vitro tissue with multiple solutions. Journal of Neurophysiology, 110 (1), pp. 269-277
- Wall, Mark J., Dale, Nicholas, 2013. Neuronal transporter and astrocytic ATP exocytosis underlie activity-dependent adenosine release in the hippocampus. The Journal of Physiology, 591 (16), pp. 3853-3871
- Kerr, Michael I., Wall, Mark J., Richardson, Magnus J. E., 2013. Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength. The Journal of Physiology, 591, pp. 3371-3380
- Forrest, Michael D., Wall, Mark J., Press, Daniel A., Feng, Jianfeng, 2012. The sodium-potassium pump controls the intrinsic firing of the cerebellar Purkinje neuron. PLoS ONE, Vol.7 (No.12)
- Klyuch, Boris P., Dale, Nicholas, Wall, Mark J., 2012. Deletion of ecto-5'-nucleotidase (CD73) reveals direct action potential-dependent adenosine release. Journal of Neuroscience, Vol.32 (No.11), pp. 3842-3847
- Klyuch, Boris P., Dale, Nicholas, Wall, Mark J., 2012. Receptor-mediated modulation of activity-dependent adenosine release in rat cerebellum. Neuropharmacology, Vol.62 (No.2), pp. 815-824
- Klyuch, Boris P., Richardson, Magnus J. E., Dale, Nicholas, Wall, Mark J., 2011. The dynamics of single spike-evoked adenosine releasein the cerebellum. Journal of Physiology, The, Vol.589 (No.2), pp. 283-295
- Atterbury, Alison, Wall, Mark J., 2011. A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia. Neuropharmacology, Vol.61 (No.4), pp. 880-888
- Wall, Mark J., Eason, Robert, Dale, Nicholas, 2010. Biosensor measurement of purine release from cerebellar cultures and slices. Purinergic Signalling, Vol.6 (No.3), pp. 339-348
- Atterbury, Alison, Wall, Mark J., 2009. Adenosine signalling at immature parallel fibre-Purkinje cell synapses in rat cerebellum. Journal of Physiology, Vol.587 (No.18), pp. 4497-4508
- Wall, Mark J., Dale, Nicholas, 2008. Activity-dependent release of Adenosine: a critical re-evaluation of mechanism. Current Neuropharmacology, Vol.6 (No.4), pp. 329-337
- Press, Daniel A., Wall, Mark J., 2008. Expression of cocaine- and amphetamine-regulated transcript (CART) peptides at climbing fibre-Purkinje cell synapses in the rat vestibular cerebellum. Neuropeptides, Vol.42 (No.1), pp. 39-46
- Sanghera, Narinder, Wall, Mark J., Venien-Bryan, Catherine, Pinheiro, Teresa J. T., 2008. Globular and pre-fibrillar prion aggregates are toxic to neuronal cells and perturb their electrophysiology. Biochimica et Biophysica Acta - Proteins and Proteomics, Vol.1784 (No.6), pp. 873-881
- Wall, Mark J., Wigmore, Geoffery, Lopatár, Ján, Frenguelli, Bruno G., Dale, Nicholas, 2008. The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacology, Vol.55 (No.7), pp. 1251-1258
- Wall, Mark J., Atterbury, Alison, Dale, Nicholas, 2007. Control of basal extracellular adenosine concentration in rat cerebellum. Journal of Physiology, Vol.582 (No.1), pp. 137-151
- Wall, Mark J., Dale, Nicholas, 2007. Auto-inhibition of rat parallel fibre-Purkinje cell synapses by activity-dependent adenosine release. Journal of Physiology, Vol.581 (No.2), pp. 553-565
- Wall, Mark J., 2023. Purinergic signaling in the cerebellum. In Gruol, D. L.; Koibuchi, N.; Manto, M.; Molinari, M; Schmahmann, J. D.; Shen, Y. (eds.), Essentials of Cerebellum and Cerebellar Disorders : A Primer For Graduate Students, Cham, Springer, pp. 225-230
- Hill, Emily, Moffat, Kevin G., Wall, Mark J., Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K., 2023. Functional applications of stable Tau Oligomers in cell biology and electrophysiology studies. In Protein Aggregation, New York, NY, Humana, pp. 147-161
- Hill, Emily, Moffat, Kevin G., Wall, Mark J., Zetterberg, Henrik, Blennow, Kaj, Karikari, Thomas K., 2022. A validated method to prepare stable Tau Oligomers. In Cieplak, A. S. (ed.), Protein Aggregation, New York, NY, Humana, pp. 203-224
- Price, Gareth W., Potter, Joe A., Williams, Bethany M., Cliff, Chelsy L., Wall, Mark J., Hills, Claire E., Squires, Paul E., 2020. Examining local cell-to-cell signalling in the kidney using ATP biosensing. In Turksen, K. (ed.), Stem Cell Renewal and Cell-Cell Communication, New York, Humana Press, pp. 135-149
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Synaptic toxicity of tau oligomers in Alzheimer's disease: underlying mechanisms and clinical translation 5-year post-doc fellowship - ARUK RAD ECF | Alzheimers Research UK | 01 Nov 2021 | 31 Oct 2026 |
| L-Aspartate signalling in the brain | MRC | 01 May 2022 | 31 May 2026 |
| MRC Mid-range Equipment Grant Full Stage Application - July 2022 | MRC | 31 Oct 2022 | 30 Oct 2025 |
| Modulation of arousal by direct CO2 gating of connexin hemichannels expressed by VTA GABAergic neurons (BBSRC Responsive Mode Application) | BBSRC | 01 Sep 2021 | 31 Jan 2025 |
| Investigating mechanisms of tau oligomer of plasticity and synaptic transmission in pyramidal cells. ARUK Midlands Network Centre | Alzheimers Research UK | 01 Mar 2021 | 28 Feb 2022 |
| ARUK ECR for Emily Hill. Mechanisms by which oligomeric tau alters neuronal function at a single neuron level: new insights into the mechanisms underlying Alzheimer's disease | Alzheimers Research UK | 15 Jul 2021 | 14 Oct 2021 |
| The role of gliotransmission in absence epilepsy | Epilepsy Research UK | 01 Sep 2017 | 31 Aug 2019 |
| How do intracellular tau protein oligomers modulate pyramidal cell function in the hippocampus? ARUK Midlands Network Centre | Alzheimers Research UK | 01 Sep 2017 | 31 Aug 2018 |
| Negative-feedback control of neocortical activity by the neuromodulator adenosine | BBSRC | 01 Jan 2013 | 31 Dec 2016 |
| Negative-feedback control of neocortical activity by the neuromodulator adenosine | BBSRC | 01 Jan 2013 | 31 Dec 2016 |
| Action Potential and Ca2+ Dependant Adenosine Release in the Cerebellum: | MRC | 01 Jun 2008 | 31 May 2011 |
| Quantifying the effects of adenosine on synaptic transmission between neocorticalpyramidal cells | Royal Society | 01 May 2009 | 30 Apr 2010 |
| Novel real-time amperometric detection of extracellular ATP: characterisation of spontaneous ATP release in cerebellum | Wellcome Trust | 01 Jan 2005 | 31 Dec 2007 |
For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Undergraduate projects: I can provide wet projects in my lab and also dry projects which will involve analysis of electrophysiology data,