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Dr Hugo van den Berg

 

Title   

Associate Professor (Reader)
 

Contact   

Mathematics
University of Warwick
Coventry
CV4 7AL
Tel: 024 7652 3698
Email: H.A.van-den-Berg@warwick.ac.uk
WebLink: http://www.maths.warwick.ac.uk/~hugo/

Research Interests

Current Research - Immunology
Dynamics and efficacy of the cellular immune system. Present research is aimed at elucidating the relationships between immune response efficacy and the statistical distributions of T cell specificities among the naive repertoire and among T cell populations which respond to given antigenic challenges. At the heart of the theory is a model of T cell receptor triggering kinetics, which relates T cell specificity to the distribution of antigenic peptide-presenting MHC molecules on the conjugate cell. This kinetic model allows us to describe how measures for T cell specificity functionally depend upon MHC-presentation levels. An example of such a specificity measure is the fraction of naive T cell clonotypes that will respond to a given antigen; another example is the rate at which cytolytic effector cells destroy target cells. Such specificity measures (as well as their distributions) underly the dynamics of T cell activation and of the ensuing effector response, which in turn determine response efficacy. The ultimate goal of this programme is to link immune efficacy in a quantitative manner MHC/antigen presentation levels on antigen-presenting cells.

Research Projects

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Publications

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