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Professor Jane Hutton

Royal Society Wolfson Research Merit Award, 2013-2017

International Biometric Society Rob Kempton Award 2016

Suffrage Science Maths and Computing Award 2016

Room D0.12, Zeeman Building. Telephone 024 7652 8357

Professor Jane Hutton works in medical statistics, with special interests in survival analysis, meta-analysis and non-random data. Her methodological research largely focuses on developing models to answer questions raised by health care colleagues, and patients. For example, collaborations with epilepsy specialists in meta-analyses led to papers on biases due to within study selection of outcomes and sub-groups, and to joint models for pre-randomisation seizure counts and post-randomised trials. Collaboration on a trial of ankle sprains has led to models for recovery rates with skew, bounded scores, with missing data.

Professor Hutton has major collaborations in cerebral palsy and epilepsy. Her work with Professor Peter Pharoah and Dr Allan Colver, on life expectancy in cerebral palsy, has had a substantial effect on the size of awards in medico-legal cases. This work is widely cited nationally and internationally. In epilepsy, she has contributed to many Cochrane reviews of anti-epileptic drugs. She has worked with Professor Tony Marson, of Liverpool University Neurosciences Department, on various projects. Recently, Professor Marson and Hutton collaborated with Professor Jim Smith to explore the role of Chain Event Graphs in modeling and managing chronic diseases.

Professor Hutton's research has had impact through clinical guidelines and in legal cases. Work in epilepsy is cited in National Institute for Clinical Excellence (NICE), SIGN and WHO guidance. Medico-legal cases have addressed life expectancy of people with cerebral palsy, spinal cord injury and traumatic brain injury, and adverse effects of drugs. Expert witness reports have been provided for cases in Australia, Canada, Eire, Hong Kong, South Africa and the four countries of the United Kingdom. The total impact is at least £100 million.

Professor Hutton has written extensively on ethics and philosophy of statistics, in response to challenges arising from medical research and discussions with international statistical colleagues and philosophers. She has contributed to Research Council ethics guidelines.

External Roles

Professor Hutton is a non-executive director and trustee of USS, from 1 November 2015. She is the Royal Statistical Society co-ordinator for a partnership between AIMS and RSS.

Professor Hutton was a member of the Core Methodology Panel, National Institute for Health Research (NIHR), 2011-2015, and the Education Committee of the International Biometric Society, 2013-2014. She was a member of the NIHR TCC Fellowship Panel, 2011-2013; the selection committee for the Health Research Board in Ireland, 2012. She has taught at AIMS South Africa, AIMS Ghana and AIMS Tanzania. Reflections on her experiences and the opportunites are here.

Zeeman Building
University of Warwick
Coventry, CV4 7AL

Tel: +44 (0)24 7652 8357
Fax: +44 (0)24 7652 4532
Email J.L.Hutton 'at '

Recent Research Grants

Defining priorities and communicating evidence about interventions for epilepsy. NIHR, with Professor AG Marson (PI) and others.

Exploring the role of Chain Event Graphs in modeling and managing chronic diseases. NIHR, with Professor J Q Smith and Professor AG Marson.

Selected recent publications

Methodological articles

JL Hutton and E Stanghellini. Modelling bounded health scores with censored skew-normal
distributions. Statist.Med., 31:368-376, 2011. DOI: 10.1002/sim.4104.

M Akacha and JL Hutton. Modelling the rate of change in a longitudinal study with missing
data, adjusting for contact attempts. Statist.Med., 30:1072-1089, 2011. DOI: 10.1002/sim.4165.

PK Kimani, E Glimm, W Maurer, JL Hutton, and N Stallard. Practical guidelines for adaptive seamless phase ii/iii clinical trials that use Bayesian methods. Statist.Med., 2012. doi: 10.1002/sim.5326.

JK Rogers and JL Hutton. Joint modelling of pre-randomisation event counts and multiple postrandomisation survival times with cure rates: application to data for early epilepsy and single seizures. J Appl. Stats, 3:546-562, 2012.

LM Barclay, JL Hutton, and JQ Smith. Refining a Bayesian Network using a Chain Event Graph. Int. J. Approx. Reason, 54:1300-1309, 2013.

LM Barclay, JL Hutton, and JQ Smith. Chain event graphs for informed missingness. Bayesian Analysis, 9:53-76, 2014.

EO Ogundimu and JLHutton. A unified approach to multilevel sample selection models. Com. Stat. Theory Methods

EO Ogundimu and JL Hutton. A sample selection model with skew-normal distribution. Scan. J. Stat, 2015. DOI:10.1111/sjos.12171

Substantive articles

P Sidebotham, B Atkins, and JL Hutton. Changes in rates of violent child deaths in England and Wales between 1974 and 2008. An analysis of national mortality data. Arch. Dis. Ch., 97:193--199, 2011. doi:10.1136/adc.2010.207647.

JK Rogers, JL Hutton, AG Marson, and DW Chadwick. Assessing the risk of subsequent tonic-clonic seizures in patients with a history of simple or complex partial seizures. J of Neurology, Neurosurgery and Psych, 83:803-809, 2012.

SM Bird and JL Hutton.Statistician expert-witnesses in agreement on relative hazards. Clin Risk, 18:58-62, 2012. doi: 10.1258/cr.2012.011056.

JL Hutton, JHW Watt, and E Wiredu. Letter commenting on ''Survival after short- or long-term ventilation
after acute spinal cord injury: a single-centre 25-year retrospective study" (Spinal Cord 2011, 49:404-410).
Spinal Cord, 2012.

GK Mbizvo, P Dixon, JL Hutton, and AG Marson. The adverse effects profile of levetiracetam in epilepsy: a more detailed look. Int J Neursci, 2012. doi:10.3109/00207454.2013.866951

Cochrane library publications

GK Mbizvo, P Dixon, JL Hutton, and AG Marson. Levetiracetam add-on for drug-resistant focal epilepsy: an updated
Cochrane review. The Cochrane Library, Issue 9:Art. No. CD001901, 2012.

J Pulman, A G Marson, and J L Hutton. Tiagabine add-on for drug-resistant patrial epilepsy. The Cochrane Library, Issue 5:Art. No. CD001908, 2012.

A Al-Bachari, J Pulman, JL Hutton, and AG Marson. Gabapentin add-on for drug resistant partial epilepsy (review).
The Cochrane Library, Issue 7:Art. No. CD001415, 2013.

Frequently requested papers

Are distinctive ethical principles required for cluster randomized controlled trials? JL Hutton, Statist. Med. 2001;20:475-488

Ethics of medical research in developing countries: the role of international codes of conduct. JL Hutton, Statistical Methods in Medical Research. 2000;9:185-206

Regional variation in survival of people with cerebral palsy in the United Kingdom. K. Hemming, JL Hutton, A Colver and MJ Platt, Pediatrics. 116:2005:1383-1390. http://10.1542/peds.2005-0259

Life expectancy in severe cerebral palsy. POD Pharoah and JL Hutton, Arch. Dis. Child. 2006;91:254-258. http://10.1136/adc.2005.075002